The ongoing pandemic Covid-19 is impacting lives of millions of people daily by mental health conditions. The current unprecedented situation demands to highlight mental issues more often and find solutions to deal with stress, anger, setting boundaries in and out of the workplace. A mandatory exhaustive list should provide solutions of how and where one can get mental health counseling probably through free E- mental health counselling, health insurances or personal at home and workplaces. A commitment towards building our understanding of mental illness, increasing access to treatment and ensuring support to those who are struggling to know they are not alone is required.

Essential tremor (ET) is involuntary tremors at upper part of body specially. The pathological neural circuits of GABAergic neuron of cerebellar dentate nucleus, brain stem (locus ceruleans and inferior olives) and thalamus is involved causes tremulous activity within the cerebellothalamocortical circuits. Nitric oxide donors, like Sodium nitroprusside, modulates the antegrade neurotransmission via retrograde neuroregulation by 10000-fold effect. The GABAergic neurons are in turn controlled by the very sensitive 10,000-fold effect circuits via Nitric Oxide. We have utilised intrathecal sodium nitroprusside superfusion (ITSNP) to induce 10000-fold effect after 2 years of failed routine conservative treatment by oral drugs like gabapentin, topiramate, trihexiphenedyl, or other drugs recommended in one ET cases. We have utilised various clinical parameters like spiral drawing (T-CALM TEST) and video recordings of routine daily activities in pre ITSNP and post ITSNP phase.

Fluconazole is a subclass of triazole antifungal agents, is available as oral tablets, powder or for oral suspension, and as a sterile solution for intravenous administration. Fluconazole is designated chemically as 2,4-difluoro-a,a1-bis benzyl alcohol in the form of white crystalline solid which is slightly soluble in water and saline. Fluconazole oral suspension contains 350 mg or 1400 mg contains sucrose, citric acid anhydrous, sodium benzoate, sodium citrate, colloidal, silicon dioxide, titanium dioxide, xanthan gum, and natural orange flavor. After reconstitution with 24 ml of distilled water or purified water each ml of reconstituted suspension contains 10 mg or 40 mg of fluconazole. Animals are divided into 4 groups. The rats of group A were taken as control group. In group B rats are kept nil per orally at 12 hours prior to induction of septic shock produce by Candida albicans s. Group C animals are administrated with fluconazole at doses of 3mg/kg, 10mg/kg and 30mg/kg after the septic shock produce by Candida albicans s. Since fluconazole at a higher dose had clearly shown to decrease tissue injury. We decided to keep fluconazole dose as constant and vitamin E would be administered in dose of 10mg/100gm of body weight in group D.

Parkinsonism is a slow but nonfatal neurodegenerative disease characterized by hypokinesia, rigidity, postural instability and tremors, due to low quantity or deficient in dopamine neurotransmitter at Substantia Nigra, parkinsonism develops in, may be be-cause of toxins, head injury or infections or drugs. Dopamine release is also regulated by NO (Nitric Oxide) which is generated by nitric oxide synthase (NOS) and NO acts via 10000-fold effect to reverse the neuronal parkinsonism clinical features. We have used intracarotid and intrathecal sodium nitroprusside to activate the 10000-fold effect to modulate the retrograde neuroregulation in Parkinsonism as a pilot study. The postural instability vanishes completely in 24 hours, loss of tremors was in just 48 hours, loss of rigidity around 5 days and hypokinesia improvement (to 75%) more than 30 days.

Objective: To assess the progress in the field clinical Parkinson’s disease (PD) in kingdom of Saudi Arabia (KSA), by analyzing in depth the research output productivity and publication pattern, and to identify the current situation of PD research and offer solutions.Method:Literature search strategy was designed to retrieve accessible articles that are related to PD utilizing PubMed, Google Scholar, and Embase. The retrieved articles were analyzed with several parameters including “journal name, impact factor, year of publica-tion, the affiliation of the first author, city, study design, population, citation numbers, study title and database”.

Background: Apathy is associated with greater caregiver burden and affects the cognitive abilities of the patient. Having a high prevalence of more than 71% in patients with dementia (PwD), it is a very common symptom in Alzheimer’s Disease (AD). In many cases it remains under-diagnosed or is misdiagnosed with depression. Methods:This study is a cross-over randomized controlled trial with 60 participants conducted in Greece. The participants were randomly assigned in 6 different groups of 10 participants each. The interventions that were evaluated are: a) Body Exercise (BE), b) Reminiscence therapy (RT) and c) Music therapy (MT). The interventions lasted for 5 days and there was two days off, as a wash-out period. There was no drop-out rate. The measurements which were used at baseline were: MMSE, ACE-R, GDS, FRSDD and NPI questionnaires.

The Objective of this study is to find the possibility of the use of both Thermotherapy [Hyperthermia][Heat Therapy] and Vibro-acoustic therapy [Vibration + Sound] to prevent and possibly reverse chronic neurological conditions like Dementia and Alzheimer’s Disease in 12 subjects over 3 months using Pre/Post Biofeedback Testing, Oximeter, Wellness IQ Questionnaire [www.academyof-wellness.com] and CBC blood test results including HBA1C. Overall Results were positive suggesting possible prevention and reversal of Dementia and Alzheimer’s using Thermotherapy and Vibroacoustic Therapy.

Mental Health has been considered as an important dimension of human health since the origin of Homo sapiens. Other dimensions such as physical, social and economic factors have also an influence on human health [1]. Mental health refers to fluid contributions of culture, religion, and socioeconomic concerns; a psychological conceptualization will still recognize some basic ingredients of mental health such as presence of mental fitness, availability (both real and perceived) of certain qualities, competencies, resources, that are potentially available to mobilize as their need arises “and not merely the absence of abnormal behavior”. According to Henderson [2], mental health signifies the operandi of an individual to pursue reasonable, purposeful goals; use his capacities and talents fruitfully.

Background:An Evans’ index (EI) greater than 0.3 has been associated with a diagnosis of idiopathic normal pressure hydrocephalus (iNPH). However, ventricular enlargement is also present in Alzheimer’s disease (AD) in the elderly. To assess the differences between ventricular enlargement in AD and iNPH, we developed a geometric model that incorporated different linear brain measurements and compared it with EI.Materials and Methods: Different ventricular linear measurements were obtained from 124 brain CT scans of normal participants, AD and iNPH patients. We developed a geometric model that yielded a linear measurement proportional to the skull shape.The maximum frontal horn distance was divided by this new tool and compared with EI to identify a cutoff point that can allow radiological differentiation between AD and iNPH

Current technologies used for glioblastoma resection seems to improve accuracy in achieving gross total resection but overall survival has been similar in the last decades with only minimal improvement. Non-enhancing areas on contrast enhanced T1-weighted MRI images has the highest density of viable malignant cells and MRI sequences are not tumor specific, making complete resection of the tumor and obtaining better survival very difficult despite the current combination of treatments. In this article we review the latest technological advances that attempt to improve tumor resection to prolong survival time

During this last time we have had to learn and investigate this new strain of coronavirus, which not only affects the respiratory tract, but also produces a systemic affection of different organs through diffuse endothellopathy and a severe systemic inflammatory response. In relation to the affection of the central nervous system, there is a direct relationship or neurotropism, through the recep-tors of the type 2 angiotensin converting enzyme (ACE2). This review tries to explain the neurological relationship and SARS-COV 2